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Identification of genes coding for B cell antigens of Mycoplasma mycoides subsp. mycoides Small Colony by using phage display
BMC Microbiology, 10/12/09

Miltiadou DR et al. – Since phage display physically couples phenotype with genotype, it could be used to compile a list of sequences that code for MmmSC proteins bearing epitopes which were recognised by antibodies in the serum of an infected animal. Together with the appropriate bioinformatic analyses, this approach provided several potentially useful vaccine or diagnostic leads. The phage display step empirically identified sequences by their interaction with antibodies which accordingly reduced the number of ORFs that had to be expressed for testing.

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