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See Latest ArticlesAntiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein
Hepatology, 10/13/09
Sakamoto N et al. – Binding of the HCV–NS5B protein to GBP–1 countered the antiviral effect by inhibition of its GTPase activity. These mechanisms may contribute to resistance to innate, IFN–mediated antiviral defense and to the clinical persistence of HCV infection.
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