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See Latest ArticlesImpaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells
Hepatology, 10/13/09
Szabo G et al. – Reduced TLR7 expression, due to RNA instability, directly correlates with HCV replication and alters TLR7–induced IRF7–mediated cell activation. These results suggest a role for TLR7 in HCV–mediated evasion of host immune surveillance.
Gyongyi Szabo, 10/13/09
| This is a first report to demonstrate TLR7 as a novel target of HCV in altering host innate immune responses. |
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