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See Latest ArticlesHomodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease Virus
Journal of Virology, 10/19/09
Brown AC et al. – The conclude that the leucine zipper is necessary for the oncogenic activity of Meq and/or the efficient establishment of long–term MDV latency in T cells. Moreover, it appears that the ability to form homodimers is an absolute requirement and the ability to bind c–Jun alone is insufficient for the T–cell lymphomagenesis associated with virulent MDV.
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