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Mechanism of Human Immunodeficiency Virus Type 1 Resistance to Monoclonal Antibody b12 That Effectively Targets the Site of CD4 Attachment
Journal of Virology, 10/12/09
Wu X et al. – To design immunogens that elicit neutralizing antibodies directed to the CD4–binding site, researchers need to address the antigenic variation within this region of gp120 and the restricted access to the CD4–binding site imposed by the native configuration of the trimeric viral envelope spike.
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Age dependency and Pseudomonas aeruginosa genotype prevalence in Dutch cystic fibrosis patients
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