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See Latest ArticlesAdaptive Mutations in a Human Immunodeficiency Virus Type 1 Envelope Protein with a Truncated V3 Loop Restore Function by Improving Interactions with CD4
Journal of Virology, 10/12/09
Agrawal–Gamse C et al. – TA1 interacted with CCR5 less efficiently and was highly sensitive to antibodies that bind to the CCR5 N terminus and ECL2. Therefore, enhanced utilization of CD4 is one mechanism by which HIV–1 can overcome mutations in the V3 region that negatively affect CCR5 interactions.
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