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DC-SIGN Mediates Cell-Free Infection and Transmission of Human T-Cell Lymphotropic Virus Type 1 by Dendritic Cells
Journal of Virology, 10/12/09
Jain P et al. – This study represents the first comprehensive analysis of potential HTLV–1 receptors on DCs and strongly suggests that DC–SIGN plays a critical role in HTLV–1 binding, transmission, and infection, thereby providing an attractive target for the development of antiretroviral therapeutics and microbicides.
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