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Regulation of Gene Expression in Primate Polyomaviruses
Journal of Virology, 10/12/09
White MK et al. – The authors discuss control mechanisms for gene expression in primate polyomaviruses, including simian vacuolating virus 40, BKV, and JCV. These mechanisms include not only modulation of promoter activities by transcription factor binding but also enhancer rearrangements, restriction of DNA methylation, alternate early mRNA splicing, cis–acting elements in the late mRNA leader sequence, and the production of viral microRNA.
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