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Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City
British Medical Journal, 10/12/09

Garcia–Garcia L et al. – Preliminary evidence suggests some protection from the 2008–9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City.

Exclusive Author Commentary
J L Valdespino, 10/13/09

Our study provides preliminary evidence suggesting some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the epidemic in Mexico City. Notwithstanding this contribution to protection, a specific vaccine against H1N1 2009 is crucial. In the coming months, October-March 2009, seasonal and pandemic influenza vaccines will become available around the world. Prospective studies need to investigate the impact of seasonal vaccination over the immunological response elicited by pandemic H1N1 2009 vaccine. Although this study provides preliminary evidence of a protective effect of seasonal vaccination against influenza A/H1N1 virus, it is prone to limitations due to small sample size and the retrospective study design. Therefore the estimates for vaccine effectiveness could be inflated owing to a high prevalence of chronic conditions and vaccination in our control population. Similar studies in other settings are needed to confirm or refute our results.

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