Infectious Dis. Medical News about Methotrexate

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A practical approach to using methotrexate
Dermatology in Practice, 10/09/09

Methotrexate is an antimetabolite that was first introduced as an anticancer drug. Due to its anti–inflammatory properties, it is now used – in much lower doses – for the treatment of joint, bowel and skin conditions. In dermatology, low–dose methotrexate is most commonly used to treat psoriasis that has not responded to topical treatments or phototherapy. It is also useful as a steroid–sparing agent in bullous pemphigoid, pemphigus, sarcoidosis, dermatomyositis and the vasculitides. Recently, it has been used in morphoea and in mycosis fungoides.

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High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: A randomised phase 2 trial
The Lancet, 11/05/09 Relevance Score: 97%

Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia
Journal of Clinical Oncology, 11/09/09 Relevance Score: 92%

Methotrexate for maintenance of remission in Crohn's disease
Cochrane Reviews, 10/27/09 Relevance Score: 90%

Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia
Cancer, 10/26/09 Relevance Score: 90%

Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias
Cancer Chemotherapy and Pharmacology, 10/05/09 Relevance Score: 90%