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Comparative Pharmacodynamics of Intermittent and Prolonged Infusions of Piperacillin/Tazobactam Using Monte Carlo Simulation and Steady-State Pharmacokinetic Data from Hospitalized Patients (November)
Annals of Pharmacotherapy, 10/15/09

Rotschafer JC et al. – With increasing antibiotic resistance in gram–negative pathogens, dosing strategies that optimize pharmacodynamic parameters of currently available antibiotics play an important role in treatment. The likelihood of success with piperacillin/tazobactam, a widely used broad–spectrum antibiotic, can be manipulated by increasing the amount of time that unbound drug concentrations remain above the pathogen's minimum inhibitory concentration (MIC).

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Evaluation of Cynomolgus Monkey PXR, Primary Hepatocyte and In Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction
Drug Metabolism and Disposition, 10/21/09 Relevance Score: 89%

Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein inhibitor, in healthy subjects
British Journal of Clinical Pharmacology, 10/20/09 Relevance Score: 89%

Antiretroviral Adherence and Pharmacokinetics: Review of their Roles in Sustained Virologic Suppression
AIDS Patient Care and STDs, 10/05/09 Relevance Score: 89%

Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in children
Acta Anaesthesiologica Scandinavica, 10/16/09 Relevance Score: 88%

Pharmacokinetic Outcomes of a Simplified, Weight-Based, Extended-Interval Gentamicin Dosing Protocol in Critically Ill Neonates
Pharmacotherapy, 10/27/09 Relevance Score: 87%