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Infective Endocarditis: Rationale for Revised Guidelines for Antibiotic Prophylaxis
Clinical Medicine & Research, 10/09/09
Gopalakrishnan PP et al. – Infective endocarditis is characterized by the presence of vegetations composed of platelets, fibrin, microorganisms, and inflammatory cells. The pathogenesis of infective endocarditis involves a complex sequence or confluence of events.4 Endothelial damage caused by turbulent blood flow seen in congenital or acquired heart disease causes platelets and fibrin deposition leading to formation of non–bacterial thrombotic endocarditis (NBTE).
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