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Spiramycin Treatment of Toxoplasma gondii Infection in Pregnant Women Impairs the Production and the Avidity Maturation of T. gondii-Specific Immunoglobulin G Antibodies
Clinical and Vaccine Immunology, 10/13/09
Meroni V et al. – The Toxoplasma gondii–specific IgG antibody and the T. gondii–specific IgG AI were significantly delayed in pregnant women receiving therapy compared to nonpregnant, untreated controls, and the findings were consistent with the results of assays from two different manufacturers. The T. gondii–specific IgG AI increased in pregnant women after they gave birth. Avidity maturation is delayed during pregnancy and treatment, and low–avidity antibodies in pregnant women within 3 to 4 months cannot be taken as a sign of infection.
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