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Eckmann C – Skin and soft tissue infections are common and account for 10% of all cases of severe sepsis. Complicated infections are defined as involving deeper layers of soft tissue, requiring substantial surgical intervention or occurring in an immunocompromised host. Distinguishing characteristics include the etiological agents, clinical presentation, depth of invasion, and local and systemic progression. Necrotizing soft tissue infections comprise a group of extremely aggressive diseases with an almost uniform diagnostic and therapeutic approach.

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