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See Latest ArticlesCardiotoxicity after low-dose chloroquine antimalarial therapy
Heart and Vessels, 10/06/09
Fragasso G et al. – The authors describe a patient with recurrent malaria, prophylactically treated with low–dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life–threatening cardiac toxicity.
Gabriele Fragasso, 10/07/09
| The article outlines the possibility that chloroquine, also at low doses, can be cardiotoxic. For those physicians often prescribing this agent, this appears as a useful information to be kept in mind in the follow-up of their patients. |
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