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Reduced prediagnostic 25-hydroxyvitamin D levels in women with breast cancer: a nested case-control study
Cancer Epidemiology, Biomarkers & Prevention, 10/01/09
Rejnmark L et al. – Use of vitamin D supplements, sunbathing frequency, and fish intake was associated with 25OHD levels, but did not affect the risk of breast cancer. Accordingly, risk of breast cancer was inversely associated with 25OHD levels
Methods- Women without a prior history of breast cancer referred to a diagnostic mammography examination
- Cases were women diagnosed with an incident breast cancer
- Controls were women not diagnosed with a breast cancer matched to cases on age, menopausal status, and time of year of blood sampling
- Characteristics of cases and controls assessed by self-administrated questionnaire
- Blood samples collected prior to diagnostic mammography examination
- Cases had lower plasma 25OHD levels than controls
- Compared with the lowest tertile of 25OHD levels, risk of breast cancer significantly reduced among women in highest tertile
- Risk estimates similar in women with estrogen receptor–positive and estrogen receptor–negative breast cancer
- Use of vitamin D supplements, sunbathing frequency, and fish intake was associated with 25OHD levels, but did not affect the risk of breast cancer
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