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The role of human endogenous retroviruses in melanoma
British Journal of Dermatology, 10/05/09
Singh S et al. – Sequencing of the human genome has established that DNA harbours many endogenous retrovirus (ERV) sequences, remnants of ancestral exogenous retroviral infections fixed in the germline DNA. In recent years, human ERVs (HERVs) have been implicated in melanomagenesis. Retrovirus–like particles and the expression of HERV mRNA and proteins have been demonstrated in melanoma tissue.
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