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Vaccinating with the genome: a Sisyphean task
Trends in Parasitology, 10/07/09
Coppel RL – The genome sequence of Plasmodium falciparum offers a large number of additional candidates, but which should be chosen? Various criteria have been suggested to rank the additional candidates, but in the absence of even a partially effective asexual–stage vaccine, the criteria remain unvalidated. These issues are discussed here, together with some suggestions as to how the development of an asexual–stage vaccine could be progressed.
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