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See Latest ArticlesIs human malarial coma caused, or merely deepened, by sequestration
Trends in Parasitology, 10/05/09
Clark IA et al. – These data are a timely call to reassess whether vascular obstruction should still be considered the primary cause of the coma of falciparum disease. They add to a growing literature that suggests that enhancement of brain–origin cytokines, such as tumour necrosis factor, by non–brain systemic inflammation and an appreciation of the degree to which neuronal homeostasis depends on them provide a more fruitful research direction.
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