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See Latest ArticlesComplementation of a Herpes Simplex Virus ICP0 Null Mutant by Varicella-Zoster Virus ORF61p
Journal of Virology, 10/05/09
Kyratsous CA et al. – A recombinant virus with each coding region of the gene for ICP0 replaced with sequences encoding ORF61p was constructed. This virus was compared to an ICP0 deletion mutant and wild–type HSV. The recombinant degraded only Sp100 and not PML and grew to higher titers than its ICP0 null parental virus, but it was sensitive to interferon, like the virus from which it was derived. This analysis permitted us to compare the activities of ICP0 and ORF61p in identical backgrounds and revealed distinct biologic roles for these proteins.
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