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See Latest ArticlesVenezuelan Equine Encephalitis Virus Disrupts STAT1 Signaling by Distinct Mechanisms Independent of Host Shutoff
Journal of Virology, 09/24/09
Simmons JD et al. – Alphaviruses are thought to limit the induction of type I IFNs and IFN–stimulated genes by shutting off host cell macromolecular synthesis, which in the case of VEEV is partially mediated by the viral capsid protein. However, more specific strategies by which alphaviruses inhibit type I IFN signaling have not been characterized.
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