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In Vivo Efficacy of 1- and 2-Gram Human Simulated Prolonged Infusions of Doripenem against Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 10/08/09
Crandon JL et al. – While MIC distributions of P. aeruginosa at present necessitate increased exposures for only the most–resistant isolates, the ability of increased doses to achieve pharmacodynamic targets and the efficacy observed when these targets were attained could prove useful when these resistant isolates are encountered.
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