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Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment
Journal of Viral Hepatitis, 09/16/09

Pene V et al. – The results firmly establish that SPP–catalysed liberation of mature core protein is absolutely dependent on prior cleavage by SP at the correct core–E1 site to generate the complete form of core protein, consistent with this obligatory order of processing playing a role in HCV infectious cycle.

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