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Survival of the fittest: allergology or parasitology
Trends in Parasitology, 09/14/09

Fitzsimmons CM et al. – Allergologists have long recognized that only a small fraction of the environmental and food proteins that the authors are exposed to give rise to IgE responses. This has raised the intriguing and important question: What makes an allergen an allergen? Many protein allergens have close homologs in metazoan parasites, and as helminth genome information grows, it appears increasingly clear that not only are the immune mechanisms of allergy and anti–helminth immunity closely related, but so are the helminth and allergen proteins that induce them.

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