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Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions
Trends in Parasitology, 09/14/09
LeRoux M et al. – Recent studies of Plasmodium falciparum isolated directly from infected patients indicate that alternative parasite biological states occur in the natural host that are not observed with in vitro cultivated parasites. Variation in host substrates, immune responses and other factors probably induce modifications in parasite biology. These biological states could have important implications for pathogenesis, transmission and therapy.
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