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Changing Patterns of Dengue Epidemiology and Implications for Clinical Management and Vaccines
PLoS Medicine, 09/04/09
Simmons CP et al. – A change in the age–burden of dengue also has implications for clinical practice. The management of severe dengue in children has been refined by clinical experience over the last 40 years and is focused on very careful replacement of the lost intravascular fluid. A priority then is to understand if other dengue–endemic countries in Southeast Asia and Central and South America are experiencing similar temporal associations between demography and dengue epidemiology, and if so, why.
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