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Role of deletion located between intermediate- and middle-region of Helicobacter pylori vacA gene in gastroduodenal diseases
Journal of Clinical Microbiology, 09/16/09
Ogiwara H et al. – The high virulent vacA genotypes significantly enhanced neutrophil infiltration and gastric atrophy in univariant analysis; whereas only vacA d–region genotype was significantly associated with neutrophil infiltration and gastric atrophy in both the antrum and the corpus in multiple linear regression analysis. The vacA d1 genotype could provide an improved predictor of H. pylori strain with histological inflammation and atrophy potential compared with vacA s–, m– and i–region genotyping in Western countries.
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