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Reporter genes facilitating discovery of drugs targeting protozoan parasites
Trends in Parasitology, 09/08/09
Dube A et al. – Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand the biology of the host–parasite interactions at the cellular level. It has provided impetus to the development of rapid and reliable drug screens both for established drugs and for new molecules against different parasites and other pathogens.
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