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Yoshikawa A et al. – The government of Japan started a selective vaccination programme to prevent mother–to–infant infection by hepatitis B virus (HBV) since January 1986. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first–time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post–transfusion HBV infection, because the horizontal transmission increases in HBV–positive blood donors.

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