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Glycine as a regulator of tryptophan-dependent pigment synthesis in Malassezia furfur
Mycoses, 08/27/09
Barchmann T et al. – The yeast–cell morphology changed from round to oval. Addition of glycine to the tryptophan–containing liquid culture stopped pigment formation with simultaneous growth induction. These in vitro on–off phenomena depending on the nitrogen source might be significant in the pathogenesis of pityriasis versicolor: hyperhidrosis followed by preferential consumption of individual nitrogen sources such as glycine with exponential growth and thereafter transamination of tryptophan and TRP–dependent pigment synthesis.
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