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Outbreak of Intestinal Infection due to Rhizopus microsporus
Journal of Clinical Microbiology, 08/06/09
Cheng VCC et al. – The primary source of the contaminating fungus was likely to be the corn starch used in the manufacturing of allopurinol tablets or ready–to–eat food. Rhizopus microsporus was thermo–tolerant and could multiply even at 50°C. The long holding time of the intermediates during the manufacturing process of allopurinol has amplified the fungal load. Microbiological monitoring of drugs manufactured for highly immunosuppressed patients should be considered.
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