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See Latest ArticlesRemaining complaints 1 year after treatment for acute Lyme neuroborreliosis; frequency, pattern and risk factors
European Journal of Neurology, 07/29/09
Ljostad U et al. – Remaining complaints, primarily subjective, are common after neuroborreliosis. Possible risk factors are: pre-treatment symptom duration ≥6 wks, high pre-treatment cerebrospinal fluid (CSF) cell count, and female gender. Presence of CSF oligoclonal bands (OCBs) may also predict a non-favorable outcome, pending further study.
Methods- Study of complaints 1 yr after treatment for neuroborreliosis, and to identify risk factors for non-favorable outcome
- Follow-up of pts prospectively treated for neuroborreliosis
- Assessment of outcome by composite clinical score
- Univariate analyses and logistic regression. analysis by impact on outcome of clinical, demographic, and laboratory factors
- Of 85 pts 41 (48%) had remaining complaints; 14 had objective findings and 27 subjective symptoms
- Remaining complaints associated with pre-treatment symptom duration ≥6 wks, high pre-treatment CSF cell count, and female gender
- Presence of CSF OCBs not analyzed in logistic regression model due to many missing observations, but was more frequent both pre-treatment and after 12 mo among pts with remaining complaints vs complete recovery
- Objective remaining findings, vs subjective symptoms, associated with pre-treatment symptom duration ≥6 wks
- No difference in outcome between pts treated with IV ceftriaxone and vs oral doxycycline
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