Infectious Dis. Medical News about C gattii

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Dexamethasone in Cryptococcus gattii Central Nervous System Infection
Clinical Infectious Diseases, 07/14/09

Phillips P et al. - Although corticosteroids are not recommended for the treatment of cryptococcal meningitis, these observations suggest that dexamethasone should be further evaluated in this subset of patients.

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Dr. Peter Phillips, 08/18/09

Dexamethasone may be beneficial in patients with C. gattii central nervous system infection who are not responding clinically to treatment with an amphotericin B formulation plus 5-flucytosine in association with both the cerebrospinal fluid (CSF) having become culture-negative and the development of new or worsening focal inflammatory brain lesions on follow-up imaging. However, risk and benefit considerations include the potential adverse effects of systemic corticosteroids. Also, dexamethasone should not be substituted as a measure to control increased intracranial pressure in the absence of an inflammatory mass lesion, where serial lumbar punctures or a CSF shunting procedure may be indicated.

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