Infectious Dis. Medical News about chronic osteomyelitis; antibiotic therapy

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Antibiotics for treating chronic osteomyelitis in adults
Cochrane Reviews, 07/23/09

Conterno LO et al. – This review identified eight small randomised trials which presented results for a total of 228 patients, most of whom were reported to have had surgical removal of the infected tissue (debridement) before starting on antibiotic therapy. There were four comparisons but pooling of results was only possible for the comparison of oral versus parenteral administration of antibiotics. Pooled results from three trials showed no statistically significant differences in the numbers of people who were without symptoms (in 'remission') at 12 months or more follow–up; nor in numbers with adverse effects or with a superinfection (another infection that is not sensitive to the antibiotic being used). This evidence suggests that the method of antibiotic administration does not have an impact on the rate of disease remission if the bacteria causing the infection are sensitive to the antibiotic used. However, confirmation is needed. There was either no or insufficient evidence to inform on the optimal duration of antibiotic therapy and on types of antibiotics.

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