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Mushatt DM et al. - Slow extended daily dialysis is the newest form of dialysis that is being used increasingly to replace continuous venovenous hemodialysis for critically ill patients; it is less expensive to administer and has similar safety for patients who are prone to hemodynamic instability. Unfortunately, there are limited data regarding the appropriate dosing of antimicrobial agents for patients undergoing SLEDD. The authors review the available pharmacokinetic data on SLEDD and give preliminary recommendations for how to approach dosing in this situation.

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