Your Article Summary
See Latest ArticlesFulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons
Annals of Neurology , 07/02/09
Wuthrich C et al. - The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. A human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer is presented.
Igor J. Koralnik, 07/07/09
| The polyomavirus JC(JCV) is the etiologic agent of progressive multifocal leukoencephalopathy(PML) and of JCV granule cell neuronopathy(JCV GCN). We present an HIV-negative patient who developed multiple cortical lesions, aphasia and progressive cognitive decline after chemotherapy for non-small-cell lung cancer. Brain biopsy and CSF PCR demonstrated JCV and she had a rapidly fatal outcome. Post-mortem analysis showed diffuse cortical lesions and areas of necrosis at the gray-white junction. Immunostaining revealed a productive JCV-infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis. |
Related Articles
Current concepts in the assessment and treatment of Hepatic Encephalopathy
QJM: An International Journal of Medicine, 11/12/09
Relevance Score: 88%
Screening of Infants for Hyperbilirubinemia to Prevent Chronic Bilirubin Encephalopathy: US Preventive Services Task Force Recommendation Statement
Pediatrics, 10/19/09
Relevance Score: 87%
Value of retinal examination in hypertensive encephalopathy
Journal of Human Hypertension, 11/03/09
Relevance Score: 85%
Systematic Review of Screening for Bilirubin Encephalopathy in Neonates
Pediatrics, 10/19/09
Relevance Score: 85%
Valproic acid-induced encephalopathy in very long course treated patients
Brain Injury, 10/22/09
Relevance Score: 84%
Today in CNS Infectious Disease...keeping you current
Receive free subspecialty "5-minute updates" via email
Tigecycline use in two cases with multidrug-resistant Acinetobacter baumannii meningitis
International Journal of Infectious Diseases, 12/07/09
Dysregulated Epstein-Barr virus infection in patients with CIDP
Journal of Neuroimmunology, 12/04/09
Limited Role of CD4+Foxp3+ Regulatory T Cells in the Control of Experimental Cerebral Malaria
Journal of Immunology, 12/04/09