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Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure
Emerging Infectious Diseases, 06/26/09

Howard SJ et al. - A population genetic analysis of microsatellites showed the existence of resistant mutants that evolved from originally susceptible strains, different cyp51A mutations in the same strain, and microalterations in microsatellite repeat number. Azole resistance in A. fumigatus is an emerging problem and may develop during azole therapy.

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