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Treatment with the Fusion Inhibitor Enfuvirtide Influences the Appearance of Mutations in the Human Immunodeficiency Virus Type 1 Regulatory Protein Rev
Antimicrobial Agents and Chemotherapy, 07/01/09
Svicher V et al. - The study shows that ENF pressure may also affect both Rev and RRE structures and can provide an excellent example of compensatory evolution. This highlights the multiple roles of ENF in modulating the correct interplay between the different HIV-1 genes and proteins during the HIV-1 life cycle.
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