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Barkai G et al. - NTHi AOM is characterized by higher occurrence in winter, bilaterality, recurrence, and previous antibiotic treatment compared with that caused by S. pneumoniae. These findings are in agreement with data associating NTHi with protracted or recurrent morbidity. The finding that S. pneumoniae and NTHi mixed episodes are more likely to occur in older children and in bilateral AOM suggests that interaction between these 2 pathogens contributes to chronicity or complexity of AOM.

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