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The eye in cerebral malaria: what can it teach us
Transactions of the Royal Society of Tropical Medicine and Hygiene, 06/25/09

Maude RJ et al. - The central mechanism causing malarial retinopathy appears to be microvascular obstruction, which has been demonstrated in affected retinas by fluorescein angiography. The presence in a central nervous system tissue of microvascular obstruction strongly supports the hypothesis that the sequestration of erythrocytes in small blood vessels and consequent obstruction of microcirculatory flow is an important mechanism causing coma and death in CM. Despite advances in the antimalarial treatment of severe malaria, its mortality remains approximately 15–20%. Adjunctive treatment targeting sequestration is a promising strategy to further lower mortality.

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