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See Latest ArticlesA brief review of potential mechanisms of immune reconstitution inflammatory syndrome in HIV following antiretroviral therapy
International Journal of STD & AIDS, 06/26/09
Mori S et al. - Following the induction of highly active ART, a rapid decline in the viral load results within weeks and coincides with a steep rise in the CD4+ T-cell counts and immune hyperactivation. Although no mechanistic pathway has been elucidated for the development of immune reconstitution inflammatory syndrome (IRIS), it is thought that change in the nature of the immune response is a predominant factor in the development of reconstitution disease. In this article, the authors review the current state of knowledge in this field and provide a model for the development of IRIS.
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