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Visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate
International Journal of Infectious Diseases, 06/23/09

Venizelos I et al. - This is a case report of a 65-year-old female with RA being treated with methotrexate, who presented with fever, abdominal discomfort, splenomegaly and pancytopenia. A diagnosis of VL was ultimately established, after a splenectomy was performed. Because RA is characterized by immune cell dysfunction and dysregulation, which potentially predisposes patients to infection, it is unclear whether this serious opportunistic infection can be solely attributable to the methotrexate, an immunosuppressive medication that also increases the risk of infection.

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