Infectious Dis. Medical News about Helicobacter pylori

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Prevalence of multidrug-resistant Helicobacter pylori in Bulgaria
Journal of Medical Microbiology, 06/16/09

Boyanova L et al. - For the first time in a European country during the last 5 years, H. pylori strains harbouring a worrying quadruple antibacterial resistance were found in treated as well as in untreated patients. H. pylori susceptibility patterns have a tendency to become unpredictable and should be monitored constantly at both national and global levels.

Exclusive Author Commentary
Lyudmila Boyanova, 06/17/09

The finding that Helicobacter pylori infection is strongly associated with the development of chronic gastritis, duodenal and gastric ulcer, gastric cancer and MALT lymphoma in humans has radically changed the treatment options of the associated diseases. Triple or quadruple regimens with two antibacterial agents or, lately, sequencial regimens are currently used to treat the infection. However, the H. pylori eradication may fail in 10-30% because of several reasons, one important reason being the antibacterial resistance. The presence of multi-drug resistant H. pylori strains harbouring triple or quadruple resistance could hinder the choice and success of the eradication regimen. Therefore, the reasons leading to eradication failure should be determined with caution for the individual patient. Susceptibility testing of the strains should be performed whenever possible. Eradication of H. pylori strains harbouring multidrug resistance requires susceptibility testing of the isolate. H. pylori susceptibility patterns tend to become unpredictable and should be monitored constantly at national and global levels. There is a growing need to evaluate new agents or combinations to treat the chronic H. pylori infection, which can carry lifelong risks for serious gastroduodenal diseases.

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