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Nosocomial outbreak of a cefepime-nonsusceptible ceftazidime-susceptible Pseudomonas aeruginosa strain overexpressing MexXY-OprM and producing an integron-borne PSE-1 beta-lactamase
Journal of Clinical Microbiology, 06/09/09
Peña C et al. - The authors identified an epidemic P. aeruginosa clone of FAPNS/CAZS phenotype strain involving 51 patients, particulary ICU patient. The combination of overexpressing efflux pump and PSE-1 beta-lactamase production is associated with the multidrug resistant phenotype. The dominant use of a single class of antibiotics could have provided the selective pressure required for emergence and spread of this P. aeruginosa strain.
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