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Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFN-gamma-induced inhibition of Chlamydia trachomatis infection
Microbial Pathogenesis, 06/04/09
Krausse-Opatz B et al. - This study demonstrates that iron acts as a regulatory element for modulating IDO expression, in addition to its function as an essential element for chlamydial growth. This may represent an important control mechanism of IDO expression at the transcriptional level.
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