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Ulett KB et al. - A more diverse spectrum of GBS serotypes than previously recognized causes UTI with the exception of nontypeable GBS.


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Glen C. Ulett, 05/27/09

Serotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized. We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections including which serotypes cause disease. GBS was cultured from 387/34,367 consecutive urine samples (1.1%). Compared with controls (who had GBS isolated without symptoms) a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotypes V, Ia, and III caused most UTI; II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes than previously recognized causes UTI with the exception of nontypeable GBS.

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