Infectious Dis. Medical News about MRSA endocarditis

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Methicillin resistant Staphylococcus aureus endocarditis in an Australian tertiary hospital: 1991–2006
Heart, Lung, and Circulation, 05/18/09

Rogers BA et al. - In an Australian setting, methicillin resistant Staphylococcus aureus (MRSA) endocarditis endocarditis was primarily nosocomial or healthcare associated. Common characteristics were older pts with multiple co-morbidities. Despite high rates of combination antibiotic therapy and surgery, mortality was very high.

Methods

Retrospective case series of MRSA endocarditis pts between 1991-2006
Subjects: 18 males (67%); median age: 64 yrs
Study of the characteristics, management, and outcomes of pts with MRSA endocarditis in an Australian hospital and trends in this group over 16 yrs

Results

Infection related to prosthetic valve or annular ring in 10 pts (37%)
Most common comorbidities: diabetes mellitus in 8 pts (30%); malignancy in 8 (30%)
Nosocomial acquisition in 16 pts (59%); non-nosocomial healthcare-associated acquisition in 10 (37%); community acquisition in 1 (4%)
Management: single antimicrobial agent in 5 pts (19%); combination antimicrobial therapy in 22 (81%)
Surgery: 16 pts (59%)
Mortality: 66%
Over 16 yrs, increased non-nosocomial acquisition and presentations to non-tertiary hospitals
No clear improvement in survival over 16 yrs

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