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Otosclerosis: an organ-specific inflammatory disease with sensorineural hearing loss
European Archives of Oto-Rhino-Laryngology, 04/06/09
Sziklai I et al. - Otosclerosis is an inflammatory disease associated with persistent measles virus (MV) infection of the otic capsule. In about one-third of stapes fixations, the etiology is non-otosclerotic stapes ankylosis. Histologic otosclerosis exhibits a strong correlation with MV presence in the bone as a sign of persistent MV infection and related inflammation with TNF-alpha release. This causes SNHL in the function of time. Non-otosclerotic stapes fixations do not cause high-frequency SNHL.
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