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Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: A pilot study
Medical Oncology, 12/14/09

Li ZY et al. – This pilot study was undertaken to assess the effect of weekly docetaxel, cisplatin and fluorouracil (DCF) as a preoperative treatment for gastric cancer with multiple synchronous hepatic metastases.

Methods

Gastric cancer patients with synchronous multiple liver metastasis were first given preoperative chemotherapy consisting of two courses (each course consisted of 6-week administration and 2-week withdrawal) of weekly DCF regimen
Following operation, postoperative chemotherapy and hepatic arterial infusion (HAI) treatment performed as required

Results

8 patients completed 2 courses of preoperative chemotherapy with weekly DCF regimen
No toxicity of grade 3 or more was observed during the course of chemotherapy
Response rate 100% according to RECIST criteria
7 patients have survived for over 1 year, and 6 of them are still alive after more than 1 year

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