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See Latest ArticlesLong-term follow-up of an age-adapted C5R protocol followed by radiotherapy in 99 newly diagnosed primary CNS lymphomas: A prospective multicentric phase II study of the Groupe d'etude des Lymphomes de l'adulte (gela)
Annals of Oncology, 11/18/09
Ghesquières H et al. – The C5R protocol was feasible in the multicentric setting with favorable long-term survival in patients younger than 60 years. Despite dose adaptation, results in older patients were disappointing.
Methods- 99 patients received age-adapted CT (C5R protocol) followed by radiotherapy
- Patients younger than 61 years (group 1, n = 45) received full C5R with MTX, doxorubicin, vincristine, cyclophosphamide, and cytarabine
- Patients aged 61–70 years (group 2, n = 36) received reduced doses
- Patients older than 70 years (group 3, n = 18) received 4 courses of MTX, cyclophosphamide, and etoposide
- Median age 63 years and 51% of patients had performance status of more than one
- 17 patients died of toxicity during CT
- CR achieved in 56%, 53%, and 28% of patients in groups 1, 2, and 3, respectively
- Median follow-up of 83 months, the 5-year PFS was 31%, 28%, and 11% and the 5-year OS 42%, 31%, and 17% for groups 1, 2, and 3, respectively
- Leukoencephalopathy occurred in 32% of assessable patients, in both group 1 and groups 2–3
Today in Diagnostics/Radiology...keeping you current
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Today in Leukemia/Lymphoma...keeping you current
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Final analysis of the UKLG LY02 trial comparing 6–8 cycles of CHOP with 3 cycles of CHOP followed by a BEAM autograft in patients <65 years with poor prognosis histologically aggressive NHL
British Journal of Haematology, 03/19/10
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High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
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